5-(4-METHYL PHENYL)-1H-TETRAZOLE

PRODUCT IDENTIFICATION
CAS NO. 24994-04-5

5-(4-METHYL PHENYL)-1H-TETRAZOLE

EINECS NO.  
FORMULA C8H8N4
MOL WT. 160.18

H.S. CODE

  

TOXICITY

  
SYNONYMS 5-(4-methyl phenyl)-1H-1,2,3,4- Tetrazole;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 244- 250 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION  

REFRACTIVE INDEX

 

NFPA RATINGS Health: 1; Flammability: 2; Reactivity: 0
FLASH POINT

 

STABILITY Stable under ordinary conditions.

APPLICATIONS
Tetrazole is one of a class of organic heterocyclic compounds containing a five-membered diunsaturated ring structure composed of four nitrogen atoms and one carbon atom. The simplest member of the tetrazole family is tetrazole itself, white to pale yellow crystalline solids with a weak characteristic odor; soluble in water and alcohol, melts at 156 C. Tetrazole is explosive. It is used as a gas generating agent for air bags. Shipment of tetrazole is available only as a solution in some countries. Tetrazole and its derivatives are used for biological activities such as antiviral, antibacterial, antifungal and antituberculous. They are used as catalysts in the synthesis of phosphonates.

Oligonucleotide is a short DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) sequence, typically made up of a few (2–20) covalently linked nucleotides. In molecular genetics, a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe for detecting complementary DNA or RNA. Oligonucleotides are currently used for genomic,proteomic and drug discovery technologies. Tetrazole is the traditional oligonucleotide synthesis activato for good coupling efficiency and to decrease the coupling times. But there are disadvantages of tetrazole; crystallisation problem from solution and potential explosive property at room temperature. Some alternatives have been recommended;

  • 5-Ethylthio-1H-tetrazole [CAS RN: 89797-68-2]
  • 5-Methylthio-1H-tetrazole [CAS RN: 29515-99-9]
  • 5-Benzylthio-1H-tetrazole [CAS RN: 21871-47-6]
  • 5-Nitrophenyl-1H-tetrazole
  • 4,5-Dicyanoimidazole [CAS RN: 1122-28-7]

    • 5-(4-Methyl phenyl)-1h-tetrazole is a side chain structure of antibiotics (Cefotaxime).
    SALES SPECIFICATION

    APPEARANCE

    		 white to off-white crystalline powder

    ASSAY

    98.0% min

    WATER

    0.5% max
    TRANSPORTATION
    PACKING

    25kgs in fiber drum

    HAZARD CLASS  
    UN NO.  
    OTHER INFORMATION